The parent carries a chromosomal rearrangement between chromosomes 11 and 22 called a balanced translocation.
2.
This rearrangement is called a balanced translocation because there is no extra material from chromosome 13.
3.
A balanced translocation or Robertsonian translocation in one of the partners leads to unviable fetuses that are miscarried.
4.
Balanced translocation in a parent increases the risk for recurrence and heritability within families ( figure 3 ).
5.
Increased rate of unexplained fetal loss may be observed in MDS carriers with balanced translocations although they may be otherwise asymptomatic.
6.
No genetic material is gained or lost in a balanced translocation, so these chromosomal changes usually do not cause any health problems.
7.
In some cases, a metacentric chromosome is formed by balanced translocation : the fusion of two acrocentric chromosomes to form one metacentric chromosome.
8.
Biological parents should be tested with fluorescence " in situ " hybridization ( FISH ) to rule out balanced translocations or inversions.
9.
The parent is usually unaffected, but carries a chromosomal rearrangement called a balanced translocation, in which no genetic material is gained or lost.
10.
For example, Slade et al . applied this method to fine map a de novo balanced translocation in a child with Wilms'tumor.
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